The event is scheduled for Dec. 8 at the KeyArena in Seattle, Washington.
MacDonald was first scheduled to face Penn on Sept. 22 at UFC 152, but during training camp at Tristar gym, one of his training partners hit the Canadian with a spinning back fist above his right eye causing a deep cut which required stitches.
With the fight just a couple of weeks away, MacDonald was force to pull out the bout, and the UFC rescheduled the fight for Dec. 8.
"I'm feeling a lot better." MacDonald told Fuel TV. "I'm able to do techniques and hit pads, strength and conditioning, and stuff like that. It brings up my spirits up a lot rather than sitting on my ass. I'm able to start my camp in about two weeks. I'm excited to get it started again.
"Its been tough, I'm ready to fight right away. I'm not one to sit on the sidelines and it seems like I can't stop getting injured in training. I'm going to have to make some changes in how I'm approaching the sport, and what I'm doing as far as taking fights and training for them. I'm going to do things my way from now on. I think it's going to let me fight a lot more, and take fights on shorter notice."
MacDonald trains at the world renown Tristar gym with current UFC welterweight champion George St. Pierre and alongside the likes of Jon Jones, Kenny Florian, Miguel Torres and others, but has grown tired of the traditional way of training for an upcoming fight.
"I'm here with a lot of the older guys," MacDonald said. "I'm learning from them, seeing how they train for fights, prepare for fights, and the two month (training camp) thing, how it has to go perfectly or whatever, you know, I'm kind of tired of all that. I just want to do things my way, fight more often."
Traditionally, fighters train eight weeks for an upcoming fight. It appears MacDonald would rather utilize an abbreviated camp and fight more often. However, though he may be unhappy with his current training regiment, and the calls his camp is making, he assures that everything is fine at Tristar.
"No, I'll be there. It's just, I have to do things my way." MacDonald said. "Not everyone is going to have the same outlook as me, but at the end of the day I'm the one getting in the cage and putting myself at risk, so I'm making the final call."